Primary Antagonists are the main villains of the series. In each season there is usually a main antagonist, who is the center cause of the trouble. And a secondary antagonist, who causes trouble, but not as regularly or big.
Season 1[]
- Main Villain(s): Georgina Sparks and Blair Waldorf
- Secondary Villain(s):Chuck Bass, Asher Hornsby
Season 2[]
- Main Villain(s): Poppy Lifton, Gabriel Edwards
- Secondary Villain(s): Chuck Bass, Blair Waldorf
- Supporting Villain(s): Serena van der Woodsen, Agnes Andrews Gabriel Edwars and Poppy Lifton
Season 3[]
- Main Villain(s): William van der Woodsen, Jenny Humphrey,
- Secondary Villain(s): Jack Bass, Tripp van der Bilt
- Supporting Villain(s): Maureen van der Bilt, Serena van der Woodsen, Damien DalgaardWilliam van der Woodsen and Jenny Humphrey
Season 4[]
- Main Villain(s): Juliet Sharp, Russell Thorpe
- Secondary Villain(s):Vanessa Abrams, Jenny Humphrey
- Supporting Villain(s): Damien Dalgaard, Carol Rhodes, Ivy Dickens
Season 5[]
- Main Villain(s):,Georgina Sparks, Louis Grimaldi and Diana Payne
- Secondary Villain(s): Ivy Dickens, Serena van der Woodsen
- Supporting Villain(s): Tripp van der Bilt Tripp van der Blit and Louis Grimaldi and Diana Payne
Season 6[]
- Main Villain(s): Bart Bass. Ivy Dickens
- Secondary Villain(s): Sage Spence, Dan Humphrey
- Supporting Villain(s): Georgina Sparks, William van der Woodsen Bart Bass and Sage Spence