The main villains of the series.
- Season 1 - Georgina Sparks, Blair Waldorf
- Season 2 - Poppy Lifton, Gabriel Edwards
- Season 3 -Jenny Humphrey, William van der Woodsen
- Season 4 - Juliet Sharp, Russell Thorpe
- Season 5 - Diana Payne, Louis Grimaldi
- Season 6 - Bart Bass, Ivy Dickens
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Ivy Dickens -
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Bart Bass -
Diana Payne -
Louis Grimaldi
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